Statistical Thermodynamics of Polymer Quantum Systems

Polymer quantum systems are mechanical models quantized similarly as loop quantum gravity. It is actually in quantizing gravity that the polymer term holds proper as the quantum geometry excitations yield a reminiscent of a polymer material. In such an approach both non-singular cosmological models and a microscopic basis for the entropy of some black holes have arisen. Also important physical questions for these systems involve thermodynamics. With this motivation, in this work, we study the statistical thermodynamics of two one dimensional {\em polymer} quantum systems: an ensemble of oscillators that describe a solid and a bunch of non-interacting particles in a box, which thus form an ideal gas. We first study the spectra of these polymer systems. It turns out useful for the analysis to consider the length scale required by the quantization and which we shall refer to as polymer length. The dynamics of the polymer oscillator can be given the form of that for the standard quantum pendulum. Depending on the dominance of the polymer length we can distinguish two regimes: vibrational and rotational. The first occur for small polymer length and here the standard oscillator in Schr\"odinger quantization is recovered at leading order. The second one, for large polymer length, features dominant polymer effects. In the case of the polymer particles in the box, a bounded and oscillating spectrum that presents a band structure and a Brillouin zone is found. The thermodynamical quantities calculated with these spectra have corrections with respect to standard ones and they depend on the polymer length. For generic polymer length, thermodynamics of both systems present an anomalous peak in their heat capacity $C_V$

Unveiling the intrinsic dynamics of biological and artificial neural networks: from criticality to optimal representations

Deciphering the underpinnings of the dynamical processes leading to information transmission, processing, and storing in the brain is a crucial challenge in neuroscience. An inspiring but speculative theoretical idea is that such dynamics should operate at the brink of a phase transition, i.e., at the edge between different collective phases, to entail a rich dynamical repertoire and optimize functional capabilities. In recent years, research guided by the advent of high-throughput data and new theoretical developments has contributed to making a quantitative validation of such a hypothesis. Here we review recent advances in this field, stressing our contributions. In particular, we use data from thousands of individually recorded neurons in the mouse brain and tools such as a phenomenological renormalization group analysis, theory of disordered systems, and random matrix theory. These combined approaches provide novel evidence of quasi-universal scaling and near-critical behavior emerging in different brain regions. Moreover, we design artificial neural networks under the reservoir-computing paradigm and show that their internal dynamical states become near critical when we tune the networks for optimal performance. These results not only open new perspectives for understanding the ultimate principles guiding brain function but also towards the development of brain-inspired, neuromorphic computation

Pasaporte COVID a examen. Nudging y derechos fundamentales

The requirement of the COVID-19 certificate by the regional Ministries of Health generalised in December 2021 to access leisure, catering and socio-healthcare establishments as an instrument to contain the pandemic and encourage vaccination limits, among others, the following fundamental rights: equality, physical integrity, privacy, freedom of movement and free enterprise. Given its novelty the literature on the topic is still in its infancy. This work analyses the legal basis of this instrument to establish such limitations, its proportionality and the constitutionality of the measure as a nudge to promote vaccination taking into account its real effectiveness and safety. The study concludes evaluating the general COVID-19 vaccination campaign’s constitutionality. Summary:I. INTRODUCTION II. PROBLEMS RAISED BY THE CERTIFICATE. III. THE LEGAL AUTHORISATION INVOKED IN THE LIGHT OF CONSTITUTIONAL JURISPRUDENCE. IV. PROPORTIONALITY OF INTERFERENCE. V. VACCINE-NUDGING.La exigencia del certificado COVID-19 por parte de las Consejerías de Salud autonómicas —generalizada en diciembre de 2021— para entrar en establecimientos de ocio y restauración y centros sociosanitarios pretendía contener la pandemia y animar a la vacunación. Dada la novedad de la medida, el desarrollo doctrinal es aún incipiente. El pasaporte COVID-19 autonómico limita, entre otros, los siguientes derechos fundamentales: igualdad en la ley, integridad física, intimidad y las libertades de circulación y de empresa. Este trabajo analiza la habilitación legal de este instrumento para establecer dichas injerencias, su proporcionalidad y la constitucionalidad de la medida como estímulo (nudge) de la vacunación teniendo en cuenta su verdadera eficacia y seguridad. Cierra el estudio una reflexión sobre la adecuación a la CE de la campaña general de vacunación contra la COVID-19

Diligencias de acceso a fuentes de prueba y responsabilidad frente a consumidores y usuarios. Una perspectiva comparada: EE. UU., Alemania y Españao 16

How pre-trial discovery works in the Spanish, US and German legal systems and its comparative application in consumers’ Law is the subject matter of this research. In light of this compared analysis, proposals are made for the upcoming transposition in the Spanish legal system of Directive (EU) 2020/1828 of the European Parliament and of the Council of 25 November 2020 on representative actions for the protection of the collective interests of consumers and repealing Directive 2009/22/EC.El presente trabajo explica en perspectiva comparada (España, EE. UU. y Alemania) la figura de las diligencias de acceso a fuentes de prueba y su aplicación a reclamaciones de responsabilidad entabladas por consumidores y usuarios en vista de la futura transposición al ordenamiento español de la Directiva 2020/1828/EU de 25 de noviembre relativa a las acciones de representación para la protección de los intereses colectivos de los consumidores, y por la que se deroga la Directiva 2009/22/CE

Gypsum-DL: an open-source program for preparing small-molecule libraries for structure-based virtual screening

Computational techniques such as structure-based virtual screening require carefully prepared 3D models of potential small-molecule ligands. Though powerful, existing commercial programs for virtual-library preparation have restrictive and/or expensive licenses. Freely available alternatives, though often effective, do not fully account for all possible ionization, tautomeric, and ring-conformational variants. We here present Gypsum-DL, a free, robust open-source program that addresses these challenges. As input, Gypsum-DL accepts virtual compound libraries in SMILES or flat SDF formats. For each molecule in the virtual library, it enumerates appropriate ionization, tautomeric, chiral, cis/trans isomeric, and ring-conformational forms. As output, Gypsum-DL produces an SDF file containing each molecular form, with 3D coordinates assigned. To demonstrate its utility, we processed 1558 molecules taken from the NCI Diversity Set VI and 56,608 molecules taken from a Distributed Drug Discovery (D3) combinatorial virtual library. We also used 4463 high-quality protein-ligand complexes from the PDBBind database to show that Gypsum-DL processing can improve virtual-screening pose prediction. Gypsum-DL is available free of charge under the terms of the Apache License, Version 2.0

Absolute dimensions of the G7+K7 eclipsing binary star IM Virginis: Discrepancies with stellar evolution models

We report extensive spectroscopic and differential photometric BVRI observations of the active, detached, 1.309-day double-lined eclipsing binary IM Vir, composed of a G7-type primary and a K7 secondary. With these observations we derive accurate absolute masses and radii of M(1) = 0.981 +/- 0.012 M(Sun), M(2) = 0.6644 +/- 0.0048 M(Sun), R(1) = 1.061 +/- 0.016 R(Sun), and R(2) = 0.681 +/- 0.013 R(Sun) for the primary and secondary, with relative errors under 2%. The effective temperatures are 5570 +/- 100 K and 4250 +/- 130 K. The significant difference in mass makes this a favorable case for comparison with stellar evolution theory. We find that both stars are larger than the models predict, by 3.7% for the primary and 7.5% for the secondary, as well as cooler than expected, by 100 K and 150 K, respectively. These discrepancies are in line with previously reported differences in low-mass stars, and are believed to be caused by chromospheric activity, which is not accounted for in current models. The effect is not confined to low-mass stars: the rapidly-rotating primary of IM Vir joins the growing list of objects of near-solar mass (but still with convective envelopes) that show similar anomalies. The comparison with the models suggests an age of 2.4 Gyr for the system, and a metallicity [Fe/H] of approximately -0.3 that is consistent with other indications, but requires confirmation.Comment: 14 pages, 13 figures. Accepted for publication in Ap

3-(Trimethyl­sil­yl)prop-2-ynyl p-toluene­sulfonate

In the title compound, C13H18O3SSi, the SO3 group displays a partial rotational (ca 50°) disorder about the C—S bond, with relative proportions 0.7744 (13):0.2256 (13). This disorder also forces the propynyl CH2 group to be disordered

Caracterización hidrogeoquímica de los manantiales del área geotermal de Ixtapan de la Sal-Tonatico (México)

La composición química del agua subterránea es el resultado de continuos procesos de interacción entre el agua de precipitación, que se infiltra en el terreno, y los minerales presentes en las rocas por donde circula. Parte de las características químicas del agua son adquiridas en la zona no saturada y otras más a lo largo de su recorrido dentro de la zona saturada, hasta donde pueden ser captadas o bien emerger como agua de manantial. Estos últimos según sus características, puede ser empleados para consumo humano, como generadores de energía o bien para fines recreativos, como es el caso de los manantiales termales de Ixtapan de la Sal y Tonatico. Los estudios hidrogeoquímicos de manantiales termales han permitido ampliar el conocimiento del origen, edad, composición físico-química de las aguas, de las condiciones de recarga y posibles mezclas de agua, así como identificar los procesos que tienen lugar en el acuífero y que permiten obtener una visión más completa del comportamiento del acuífero. También permiten deducir las características de la roca, composición mineralógica, textura, porosidad, grado de alteración, fracturación y compactación, tiempo de residencia o de contacto, temperatura y presión..

Laser Ablation Surface Preparation of Ti-6A1-4V for Adhesive Bonding

Adhesive bonding offers many advantages over mechanical fastening, but requires certification before it can be incorporated in primary structures for commercial aviation without disbond-arrestment features or redundant load paths. Surface preparation is widely recognized as the key step to producing robust and predictable bonds. Laser ablation imparts both topographical and chemical changes to a surface which can lead to increased bond durability. A laser based process provides an alternative to chemical-dip, manual abrasion and grit blast treatments which are expensive, hazardous, polluting, and less precise. This report documents preliminary testing of a surface preparation technique using laser ablation as a replacement for the chemical etch and abrasive processes currently applied to Ti-6Al-4V alloy adherends. Failure mode, surface roughness, and chemical makeup were analyzed using fluorescence enhanced visualization, microscopy, and X-ray photoelectron spectroscopy, respectively. Single lap shear tests were conducted on bonded and aged specimens to observe bond strength retention and failure mode. Some promising results showed increasing strength and durability of lap shear specimens as laser ablation coverage area and beam intensity increased. Chemical analyses showed trends for surface chemical species which correlated with improved bond strength and durability. Combined, these results suggest that laser ablation is a viable process for inclusion with or/and replacement of one or more currently used titanium surface treatments. On-going work will focus on additional mechanical tests to further demonstrate improved bond durability

Hydrotherapy for the Treatment of Pain in People with Multiple Sclerosis: A Randomized Controlled Trial

Background. Multiple sclerosis (MS) is a chronic demyelinating neurological disease. Several studies have reported that complementary and alternative therapies can have positive effects against pain in these patients. Objective. The objective was to investigate the effectiveness of an Ai-Chi aquatic exercise program against pain and other symptoms in MS patients. Methods. In this randomized controlled trial, 73 MS patients were randomly assigned to an experimental or control group for a 20-week treatment program. The experimental group underwent 40 sessions of Ai-Chi exercise in swimming pool and the control group 40 sessions of abdominal breathing and contraction-relaxation exercises in therapy room. Outcome variables were pain, disability, spasm, depression, fatigue, and autonomy, which were assessed before the intervention and immediately and at 4 and 10 weeks after the last treatment session. Results. The experimental group showed a significant (P < 0.028) and clinically relevant decrease in pain intensity versus baseline, with an immediate posttreatment reduction in median visual analogue scale scores of 50% that was maintained for up to 10 weeks. Significant improvements were also observed in spasm, fatigue, disability, and autonomy. Conclusion. According to these findings, an Ai-Chi aquatic exercise program improves pain, spasms, disability, fatigue, depression, and autonomy in MS patients